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Therapy Name | Anti-CD37 CAR T cells |
Synonyms | |
Therapy Description |
Anti-CD37 CAR T cells consist of T-lymphocytes engineered to express a chimeric antigen receptor (CAR) that targets CD37 and contains a CD8 transmembrane domain linked to CD137 (4-1BB) and CD3 zeta signaling domains, which potentially induces cytotoxicty against tumor cells expressing CD37, and reduces tumor burden (PMID: 30089630). |