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Therapy Name CLL-1 CAR-T cells
Synonyms
Therapy Description

CLL-1 CAR-T cells consist of T-lymphocytes engineered to express a chimeric antigen receptor (CAR) that targets CLL1 and contains CD28 and CD137 (4-1BB) costimulatory and CD3 zeta signaling domains, which potentially induces lysis of tumor cells expressing CLL1 and reduces tumor burden (PMID: 29316944).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
CLL-1 CAR-T cells CLL1 CAR-T cells|anti-CLL1 CART cells CLL-1 CAR-T cells consist of T-lymphocytes engineered to express a chimeric antigen receptor (CAR) that targets CLL1 and contains CD28 and CD137 (4-1BB) costimulatory and CD3 zeta signaling domains, which potentially induces lysis of tumor cells expressing CLL1 and reduces tumor burden (PMID: 29316944).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04219163 Phase I CLL-1 CAR-T cells Chimeric Antigen Receptor T-cells for The Treatment of AML Expressing CLL-1 Antigen Recruiting USA 0


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