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Therapy Name CUE-101
Synonyms
Therapy Description

CUE-101 is a fusion protein consisting of an HLA-A*0201 complex linked to an HPV16 E7 epitope (aa 11-20), a reduced affinity version of interleukin-2, and an effector attenuated IgG1 Fc domain, which binds to HPV16 E7-specific T-cells, potentially activating a T-cell response against HPV16 E7-positive tumor cells (PMID: 31964784).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
CUE-101 CUE101|CUE 101|anti-HPV16 E7 fusion protein CUE-101 CUE-101 is a fusion protein consisting of an HLA-A*0201 complex linked to an HPV16 E7 epitope (aa 11-20), a reduced affinity version of interleukin-2, and an effector attenuated IgG1 Fc domain, which binds to HPV16 E7-specific T-cells, potentially activating a T-cell response against HPV16 E7-positive tumor cells (PMID: 31964784).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04852328 Phase II CUE-101 Three Schedules of CUE-101 Administered Before Surgery or Definitive Chemoradiation Therapy in HLA-A*0201 Positive Patients With Locally Advanced, HPV16-Positive Oropharyngeal Squamous-Cell Carcinoma Recruiting USA 0
NCT03978689 Phase I CUE-101 + Pembrolizumab CUE-101 A Phase 1 Study in Patients With HPV16+ Recurrent/ Metastatic Head and Neck Squamous Cell Carcinoma Active, not recruiting USA 0


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