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Therapy Name HPN217
Synonyms
Therapy Description

HPN217 is a tri-specific molecule that targets BCMA (TNFRSF17) and CD3 epsilon domain (CD3e), as well as human serum albumin, which potentially results in activation of T-cell response and increased death of BCMA-expressing tumor cells (Blood (2018) 132 (Supplement 1): 3225).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
HPN217 HPN-217|TriTAC HPN 217|Anti-BCMA/CD3e TriTAC HPN217 CD3 Antibody 99 TNFRSF17 Antibody 20 HPN217 is a tri-specific molecule that targets BCMA (TNFRSF17) and CD3 epsilon domain (CD3e), as well as human serum albumin, which potentially results in activation of T-cell response and increased death of BCMA-expressing tumor cells (Blood (2018) 132 (Supplement 1): 3225).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04184050 Phase Ib/II HPN217 A Phase 1/2 Open-label, Multicenter, Dose Escalation and Dose Expansion Study of the Safety, Tolerability, and PK of HPN217 in Patients With R/R MM Active, not recruiting USA | FRA | ESP 0


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