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Therapy Name anti-GPC3-IL15-iC9-expressing CAR T-cells
Synonyms
Therapy Description

anti-GPC3-IL15-iC9-expressing CAR T-cells are autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting GPC3, and co-express IL15 and inducible caspase 9 (iC9), which potentially induce antitumor activity (PMID: 39604730).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
anti-GPC3-IL15-iC9-expressing CAR T-cells CATCH T-cells|AGAR T-cells|CATCH T cells|GO CART T-cells GPC3 Immune Cell Therapy 8 anti-GPC3-IL15-iC9-expressing CAR T-cells are autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting GPC3, and co-express IL15 and inducible caspase 9 (iC9), which potentially induce antitumor activity (PMID: 39604730).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05103631 Phase I anti-GPC3-IL15-iC9-expressing CAR T-cells Interleukin-15 Armored Glypican 3-specific Chimeric Antigen Receptor Expressed in Autologous T Cells for Solid Tumors Recruiting USA 0
NCT04377932 Phase I Cyclophosphamide + Fludarabine anti-GPC3-IL15-iC9-expressing CAR T-cells Interleukin-15 Armored Glypican 3-specific Chimeric Antigen Receptor Expressed in T Cells for Pediatric Solid Tumors Active, not recruiting USA 0
NCT06815432 Phase I anti-GPC3-IL15-iC9-expressing CAR T-cells GPC-3 CAR T CELLS for Recurrent GPC-3 Positive Glioblastoma Not yet recruiting USA 0


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