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Therapy Detail
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| Therapy Name | AB680 + Etrumadenant |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| AB680 | AB-680|AB 680|quemliclustat | Adenosine Targeting 24 CD73 Antibody 13 | AB680 is an inhibitor that selectively targets CD73, resulting in decreased production of extracellular adenosine (ADO), and potentially leading to decreased ADO-mediated T-cell suppression and improved anti-tumor immunity (Cancer Res 2018;78(13 Suppl):Abstract nr 1756, PMID: 32614585). | |
| Etrumadenant | AB 928|AB-928|AB928 | Adenosine Targeting 24 | Etrumadenant is an antagonist of the adenosine receptors, A2aR and A2bR, which may relieve adenosine-mediated immune suppression and lead to enhanced anti-tumor activity in combination with other agents (European Journal of Cancer, Vol 92, S14-S15, PMID: 30569245). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04381832 | Phase Ib/II | Enzalutamide + Etrumadenant + Zimberelimab Docetaxel + Etrumadenant + Zimberelimab AB680 + Etrumadenant + Zimberelimab AB680 + Etrumadenant Enzalutamide Docetaxel Etrumadenant + Zimberelimab | Adenosine Receptor Antagonist Combination Therapy for Metastatic Castrate Resistant Prostate Cancer (ARC-6) | Completed | USA | CAN | 0 |
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