Therapy Detail
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| Therapy Name | JNJ-63709178 |
| Synonyms | |
| Therapy Description |
JNJ-63709178 is a bispecific antibody that binds to IL3RA (CD123) and CD3, which activates cytotoxic T-lymphocyte response against IL3RA-expressing tumor cells, potentially inducing cytotoxic killing of tumor cells expressing IL3RA (Blood (2016) 128 (22): 2824). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| JNJ-63709178 | JNJ 63709178|Anti-CD123/CD3 Bispecific Antibody JNJ63709178 | CD123 (IL3RA) Antibody 14 CD3 Antibody 119 | JNJ-63709178 is a bispecific antibody that binds to IL3RA (CD123) and CD3, which activates cytotoxic T-lymphocyte response against IL3RA-expressing tumor cells, potentially inducing cytotoxic killing of tumor cells expressing IL3RA (Blood (2016) 128 (22): 2824). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT02715011 | Phase I | JNJ-63709178 | Dose Escalation Study of JNJ-63709178, a Humanized CD123 x CD3 DuoBody in Participants With Relapsed or Refractory Acute Myeloid Leukemia (AML) | Completed | USA | ESP | 0 |
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