Therapy Detail
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| Therapy Name | Decitabine and Cedazuridine + Tolinapant |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Decitabine and Cedazuridine | Inqovi | ASTX-727|ASTX 727|ASTX727 | Chemotherapy - Antimetabolite 14 | Inqovi (decitabine and cedazuridine) is a combination of decitabine and cedazuridine, which may inhibit proliferation of tumor cells (PMID: 30926081). Inqovi (decitabine and cedazuridine) is an FDA approved chemotherapy agent (FDA.gov). |
| Tolinapant | ASTX660|ASTX 660|ASTX-660 | SMAC Mimetic 8 | Tolinapant (ASTX-660) is a SMAC mimetic that inhibits cIAP and XIAP, potentially resulting in tumor cell death (PMID: 40353748, PMID: 31900279). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04155580 | Phase I | Tolinapant Decitabine and Cedazuridine + Tolinapant | A Study of ASTX660 as a Single Agent and in Combination With ASTX727 in Subjects With Relapsed/Refractory Acute Myeloid Leukemia (AML) | Terminated | USA | 0 |
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