Therapy Detail
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| Therapy Name | ETBX-051 + ETBX-061 + ETBX-071 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| ETBX-051 | ETBX051|ETBX 051 | ETBX-051 is a virally based vaccine that infects cells and induces expression of the brachyury protein protein, which may activate the immune system to elicit a cytotoxic T-lymphocyte (CTL) response against brachyury expressing tumor cells (PMID: 31594913). | ||
| ETBX-061 | ETBX061|ETBX 061 | ETBX-061 is a virally based vaccine that infects cells and causes expression of the Muc1 protein, which may activate the immune system to elicit a cytotoxic T-lymphocyte (CTL) response against Muc1 expressing tumor cells (PMID: 31594913). | ||
| ETBX-071 | ETBX 071|ETBX071|Adenoviral PSA Vaccine ETBX-071 | ETBX-071 is an engineered adenovirus vaccine that expresses human prostate specific antigen (PSA) in infected cells, which potentially activates cytotoxic T-lymphocytes against tumor cells expressing PSA (NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03481816 | Phase I | ETBX-051 + ETBX-061 + ETBX-071 | Treatment of Castration Resistant Prostate Cancer Using Multi-Targeted Recombinant Ad5 PSA/MUC1/Brachyury Based Immunotherapy Vaccines | Completed | USA | 0 |
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