Therapy Detail
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| Therapy Name | A-419259 |
| Synonyms | |
| Therapy Description |
A-419259 is an multi-kinase inhibitor with activity against Src family of kinases, including Hck, Fgr, Lyn, Flt3, and wild-type FLT3-ITD, potentially resulting in reduced viability of tumor cells (PMID: 31790499). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| A-419259 | RK-20449|RK20449|RK 20449|A 419259|A419259 | FLT3 Inhibitor 69 LYN Inhibitor 4 | A-419259 is an multi-kinase inhibitor with activity against Src family of kinases, including Hck, Fgr, Lyn, Flt3, and wild-type FLT3-ITD, potentially resulting in reduced viability of tumor cells (PMID: 31790499). |
Filtering
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FLT3 exon 14 ins | acute myeloid leukemia | sensitive | A-419259 | Preclinical - Cell culture | Actionable | In a preclinical study, A-419259 treatment inhibited viability of an acute myeloid leukemia cell line harboring FLT3-ITD in culture (PMID: 31790499). | 31790499 |
| FLT3 exon 14 ins FLT3 D835Y | myeloid leukemia | resistant | A-419259 | Preclinical - Cell culture | Actionable | In a preclinical study, transformed myeloid leukemia cells co-expressing FLT-ITD and FLT3 D835Y demonstrated resistance to A-419259 treatment in culture (PMID: 31790499). | 31790499 |
| FLT3 exon 14 ins | myeloid leukemia | sensitive | A-419259 | Preclinical - Cell culture | Actionable | In a preclinical study, transformed myeloid leukemia cells expressing FLT3-ITD were sensitive to treatment with A-419259, demonstrating inhibition of cell growth in culture (PMID: 31790499). | 31790499 |
| FLT3 exon 14 ins FLT3 N676S | myeloid leukemia | resistant | A-419259 | Preclinical - Cell culture | Actionable | In a preclinical study, transformed myeloid leukemia cells co-expressing FLT-ITD and FLT3 N676S demonstrated resistance to A-419259 treatment in culture (PMID: 31790499). | 31790499 |
| FLT3 exon 14 ins FLT3 F691L | myeloid leukemia | resistant | A-419259 | Preclinical - Cell culture | Actionable | In a preclinical study, transformed myeloid leukemia cells co-expressing FLT-ITD and FLT3 F691L demonstrated resistance to A-419259 treatment in culture (PMID: 31790499). | 31790499 |
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|
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