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Therapy Name	A-419259
Synonyms
Therapy Description	A-419259 is an multi-kinase inhibitor with activity against Src family of kinases, including Hck, Fgr, Lyn, Flt3, and wild-type FLT3-ITD, potentially resulting in reduced viability of tumor cells (PMID: 31790499).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
A-419259		RK-20449\|RK20449\|RK 20449\|A 419259\|A419259	FLT3 Inhibitor 69 LYN Inhibitor 4	A-419259 is an multi-kinase inhibitor with activity against Src family of kinases, including Hck, Fgr, Lyn, Flt3, and wild-type FLT3-ITD, potentially resulting in reduced viability of tumor cells (PMID: 31790499).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
FLT3 exon 14 ins	acute myeloid leukemia	sensitive	A-419259	Preclinical - Cell culture	Actionable	In a preclinical study, A-419259 treatment inhibited viability of an acute myeloid leukemia cell line harboring FLT3-ITD in culture (PMID: 31790499).	31790499
FLT3 exon 14 ins	myeloid leukemia	sensitive	A-419259	Preclinical - Cell culture	Actionable	In a preclinical study, transformed myeloid leukemia cells expressing FLT3-ITD were sensitive to treatment with A-419259, demonstrating inhibition of cell growth in culture (PMID: 31790499).	31790499
FLT3 exon 14 ins FLT3 D835Y	myeloid leukemia	resistant	A-419259	Preclinical - Cell culture	Actionable	In a preclinical study, transformed myeloid leukemia cells co-expressing FLT-ITD and FLT3 D835Y demonstrated resistance to A-419259 treatment in culture (PMID: 31790499).	31790499
FLT3 exon 14 ins FLT3 F691L	myeloid leukemia	resistant	A-419259	Preclinical - Cell culture	Actionable	In a preclinical study, transformed myeloid leukemia cells co-expressing FLT-ITD and FLT3 F691L demonstrated resistance to A-419259 treatment in culture (PMID: 31790499).	31790499
FLT3 exon 14 ins FLT3 N676S	myeloid leukemia	resistant	A-419259	Preclinical - Cell culture	Actionable	In a preclinical study, transformed myeloid leukemia cells co-expressing FLT-ITD and FLT3 N676S demonstrated resistance to A-419259 treatment in culture (PMID: 31790499).	31790499

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