Therapy Detail
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| Therapy Name | Azenosertib + Carboplatin |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Azenosertib | ZNc3|ZN c3|ZN-c3 | WEE1 Inhibitor 8 | Azenosertib inhibits WEE1, which potentially increases DNA damage leading to induction of apoptosis, decreased tumor cell proliferation, and inhibition of tumor growth (PMID: 40231599, PMID: 39755818). | |
| Carboplatin | Paraplatin | CBDCA | Chemotherapy - Platinum 7 | Paraplatin (carboplatin) is a second-generation platinum compound and is activated intracellularly to form reactive platinum complexes that cross link DNA with DNA and with proteins. This induces apoptosis and inhibits cell growth (NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04516447 | Phase I | Azenosertib + Pegylated liposomal doxorubicin Azenosertib + Carboplatin | A Study of ZN-c3 in Patients With Platinum-Resistant Ovarian Cancer | Recruiting | USA | BGR | AUS | 4 |
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