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Therapy Name IGM-8444
Synonyms
Therapy Description

IGM-8444 is a multivalent agonistic antibody that targets and activates Death Receptor 5 (TNFRSF10B), potentially resulting in increased cytotoxicity and apoptosis, and inhibition of tumor growth (Journal of Clinical Oncology 2020 38:15_suppl, 3595; Cancer Res 2020;80(16 Suppl):Abstract nr 518).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
IGM-8444 IGM8444|IGM 8444 IGM-8444 is a multivalent agonistic antibody that targets and activates Death Receptor 5 (TNFRSF10B), potentially resulting in increased cytotoxicity and apoptosis, and inhibition of tumor growth (Journal of Clinical Oncology 2020 38:15_suppl, 3595; Cancer Res 2020;80(16 Suppl):Abstract nr 518).

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04553692 Phase I Bevacizumab + Fluorouracil + IGM-8444 + Irinotecan + Leucovorin Fluorouracil + IGM-8444 + Irinotecan + Leucovorin IGM-8444 Study of IGM-8444 as a Single Agent and in Combination With Chemotherapy-based Regimens in Subjects With Solid Cancers Active, not recruiting USA | FRA | ESP | AUS 1


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