Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Drug Name | IGM-8444 |
Trade Name | |
Synonyms | IGM8444|IGM 8444 |
Drug Descriptions |
IGM-8444 is a multivalent agonistic antibody that targets and activates Death Receptor 5 (TNFRSF10B), potentially resulting in increased cytotoxicity and apoptosis, and inhibition of tumor growth (Journal of Clinical Oncology 2020 38:15_suppl, 3595; Cancer Res 2020;80(16 Suppl):Abstract nr 518). |
DrugClasses | |
CAS Registry Number | NA |
NCIT ID | C176625 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Bevacizumab + Fluorouracil + IGM-8444 + Irinotecan + Leucovorin | Bevacizumab Fluorouracil IGM-8444 Irinotecan Leucovorin | 0 | 1 |
Fluorouracil + IGM-8444 + Irinotecan + Leucovorin | Fluorouracil IGM-8444 Irinotecan Leucovorin | 0 | 1 |
IGM-8444 | IGM-8444 | 0 | 1 |