Therapy Detail
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| Therapy Name | Idronoxil + Paclitaxel |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Idronoxil | Phenoxodiol|NV-06|3-(4-Hydroxyphenyl)-2H-1-benzopyran-7-ol | Idronoxil is an isoflavone analog that leads to decreased Cdk2 activity (PMID: 15833870) and activation of the mitochondrial caspase pathway, and may lead to cell cycle arrest and apoptosis (PMID: 16388521) and decreased proliferation of tumor cells (PMID: 20564423). | ||
| Paclitaxel | Taxol | 7-Epipaclitaxel | Antimicrotubule Agent 14 BCL2 Family Inhibitor 6 | Taxol (paclitaxel) binds to tubulin to inhibit microtubule disassembly, which results in decreased cell division, and also binds to the anti-apoptotic factor Bcl-2, promoting apoptosis (NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|
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