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Therapy Name	AZ628
Synonyms
Therapy Description	AZ628 is an irreversible pan-RAF inhibitor with activity against RAF1 and BRAF, including BRAF V600E, which leads to increased cell-cycle arrest and apoptosis of tumor cells (PMID: 18020980, PMID: 23288408).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
AZ628		AZD628\|AZD-628	RAF Inhibitor (Pan) 29	AZ628 is an irreversible pan-RAF inhibitor with activity against RAF1 and BRAF, including BRAF V600E, which leads to increased cell-cycle arrest and apoptosis of tumor cells (PMID: 18020980, PMID: 23288408).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
BRAF D594G NRAS G12D	melanoma	sensitive	AZ628	Preclinical - Cell culture	Actionable	In a preclinical study, AZ628 inhibited proliferation of melanoma cell lines harboring both BRAF D594G and NRAS G12D in culture (PMID: 27523909).	27523909
BRAF G466E	melanoma	sensitive	AZ628	Preclinical - Cell culture	Actionable	In a preclinical study, AZ628 inhibited proliferation of melanoma cell lines harboring BRAF G466E in culture (PMID: 27523909).	27523909
BRAF L597V NRAS Q61K	lung non-small cell carcinoma	sensitive	AZ628	Preclinical - Cell culture	Actionable	In a preclinical study, AZ628 inhibited proliferation of non-small cell lung cancer cells harboring both BRAF L597V and NRAS Q61K in culture (PMID: 27523909).	27523909
BRAF N486_P490del	ovarian cancer	sensitive	AZ628	Preclinical - Cell culture	Actionable	In a preclinical study, an ovarian cancer cell line harboring BRAF N486_P490del demonstrated sensitivity to AZ628, resulting in decreased cell viability and inhibition of Mek and Erk phosphorylation in culture (PMID: 26996308).	26996308
BRAF N486_P490del	melanoma	sensitive	AZ628	Preclinical - Cell culture	Actionable	In a preclinical study, a melanoma cell line harboring BRAF N486_P490del demonstrated sensitivity to AZ628, resulting in decreased cell viability and inhibition of Mek and Erk phosphorylation in culture (PMID: 26996308).	26996308
BRAF V600D	melanoma	sensitive	AZ628	Preclinical - Cell culture	Actionable	In a preclinical study, AZ628 inhibited proliferation of melanoma cell lines harboring BRAF V600D in culture (PMID: 27523909).	27523909
BRAF V600E	melanoma	sensitive	AZ628	Preclinical - Cell culture	Actionable	In a preclinical study, AZ628 inhibited proliferation of melanoma cell lines harboring either monomeric BRAF V600E or dimeric isoform of V600E which conferred Zelboraf (vemurafenib)-resistance in culture (PMID: 27523909).	27523909
BRAF V600R	melanoma	sensitive	AZ628	Preclinical - Cell culture	Actionable	In a preclinical study, AZ628 inhibited proliferation of melanoma cell lines harboring BRAF V600R in culture (PMID: 27523909).	27523909
BRAF wild-type NRAS wild-type	melanoma	sensitive	AZ628	Preclinical - Cell culture	Actionable	In a preclinical study, AZ628 inhibited proliferation of BRAF and NRAS wild-type melanoma cells in culture (PMID: 27523909).	27523909

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