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Drug Name | AZ628 |
Trade Name | |
Synonyms | AZD628|AZD-628 |
Drug Descriptions |
AZ628 is an irreversible pan-RAF inhibitor with activity against RAF1 and BRAF, including BRAF V600E, which leads to increased cell-cycle arrest and apoptosis of tumor cells (PMID: 18020980, PMID: 23288408). |
DrugClasses | RAF Inhibitor (Pan) 28 |
CAS Registry Number | 878739-06-1 |
NCIT ID | NA |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
AZ628 | AZ628 | 9 | 0 |
AZ628 + CPI-455 | AZ628 CPI-455 | 0 | 0 |
AZ628 + Selumetinib | AZ628 Selumetinib | 1 | 0 |
AZ628 + Trametinib | AZ628 Trametinib | 0 | 0 |
AZ628 + VX-11e | AZ628 VX-11e | 0 | 0 |