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Therapy Name CX-072 + CX-2009
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
CX-072 CX072|CX 072|Pacmilimab Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 121 CX-072 (Pacmilimab) is a prodrug consisting of a monoclonal antibody to PD-L1 (CD274) and a masking peptide that is cleaved by proteases specific to tumor cells (Journal of Clinical Oncology 36, no. 15_suppl (May 20 2018) 3072-3072, PMID: 32681519).
CX-2009 CX2009|CX 2009|praluzatamab ravtansine CX-2009 (praluzatamab ravtansine) is a probody drug conjugate consisting of the cytotoxic agent, maytansinoid DM4, and an antibody to the tumor associate antigen, CD166 (ALCAM), with a masking peptide that is cleaved by proteases specific to tumor cells (PMID: 32483421).

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04596150 Phase II CX-2009 CX-072 + CX-2009 Study to Evaluate the Safety and Antitumor Activity of CX-2009 Monotherapy and in Combination With CX-072 in Advanced Breast Cancer Completed USA | ESP 1


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