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Therapy Name Metarrestin
Synonyms
Therapy Description

Metarrestin is a small molecule drug that inhibits the assembly of the perinucleolar compartment, leading to disruption of the nucleolar structure and inhibition of RNA polymerase I transcription, which may result in decreased metastasis, including reduced cell growth and invasion and decreased tumor growth (PMID: 29769289).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Metarrestin ML-246|ML 246|ML246 Metarrestin is a small molecule drug that inhibits the assembly of the perinucleolar compartment, leading to disruption of the nucleolar structure and inhibition of RNA polymerase I transcription, which may result in decreased metastasis, including reduced cell growth and invasion and decreased tumor growth (PMID: 29769289).

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04222413 Phase I Metarrestin Metarrestin (ML-246) in Subjects With Metastatic Solid Tumors Recruiting USA 0


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