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Therapy Name	LT-171-861
Synonyms
Therapy Description	LT-171-861 inhibits FLT3 with activity against FLT3-ITD, as well as PIM2, potentially resulting in decreased tumor growth (PMID: 33391463, PMID: 34111425).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
LT-171-861			FLT3 Inhibitor 69	LT-171-861 inhibits FLT3 with activity against FLT3-ITD, as well as PIM2, potentially resulting in decreased tumor growth (PMID: 33391463, PMID: 34111425).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
FLT3 exon 14 ins	acute myeloid leukemia	sensitive	LT-171-861	Preclinical - Cell line xenograft	Actionable	In a preclinical study, LT-171-861 inhibited cell growth, decreased FLT3 signaling, and induced apoptosis in acute myeloid leukemia cell lines and primary patient-derived peripheral blood mononuclear cells harboring FLT3-ITD mutations in culture, and resulted in tumor regression and prolonged survival in cell line xenograft models (PMID: 33391463).	33391463
FLT3 exon 14 ins FLT3 F691L	hematologic cancer	sensitive	LT-171-861	Preclinical - Cell line xenograft	Actionable	In a preclinical study, LT-171-861 inhibited cell viability and decreased FLT3 phosphorylation in transformed cells expressing a FLT3-ITD mutation and FLT3 F691L in culture, and inhibited tumor growth and prolonged survival in cell line xenograft models (PMID: 33391463).	33391463
FLT3 exon 14 ins FLT3 N676D	hematologic cancer	sensitive	LT-171-861	Preclinical - Cell line xenograft	Actionable	In a preclinical study, LT-171-861 inhibited cell viability and decreased FLT3 phosphorylation in transformed cells expressing a FLT3-ITD mutation and FLT3 N676D in culture, and inhibited tumor growth and prolonged survival in cell line xenograft models (PMID: 33391463).	33391463
FLT3 D835Y	hematologic cancer	sensitive	LT-171-861	Preclinical - Cell culture	Actionable	In a preclinical study, LT-171-861 inhibited cell viability and decreased FLT3 phosphorylation in transformed cells expressing FLT3 D835Y in culture (PMID: 33391463).	33391463
FLT3 exon 14 ins	hematologic cancer	sensitive	LT-171-861	Preclinical - Cell culture	Actionable	In a preclinical study, LT-171-861 inhibited cell viability and decreased FLT3 phosphorylation in transformed cells expressing a FLT3-ITD mutation in culture (PMID: 33391463).	33391463
FLT3 exon 14 ins FLT3 D835Y	hematologic cancer	predicted - sensitive	LT-171-861	Preclinical - Cell culture	Actionable	In a preclinical study, LT-171-861 inhibited cell viability and decreased FLT3 phosphorylation in transformed cells expressing a FLT3-ITD mutation and FLT3 D835Y in culture (PMID: 33391463).	33391463
FLT3 exon 14 ins FLT3 Y842C	hematologic cancer	sensitive	LT-171-861	Preclinical - Cell culture	Actionable	In a preclinical study, LT-171-861 inhibited cell viability and decreased FLT3 phosphorylation in transformed cells expressing a FLT3-ITD mutation and FLT3 Y842C in culture (PMID: 33391463).	33391463

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