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Therapy Name	C220
Synonyms
Therapy Description	C220 is a small molecule inhibitor that selectively targets PRMT5, which may lead to decreased cell proliferation and reduced secretion of cytokines (PMID: 32669286).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
C220			PRMT5 Inhibitor 20	C220 is a small molecule inhibitor that selectively targets PRMT5, which may lead to decreased cell proliferation and reduced secretion of cytokines (PMID: 32669286).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
JAK2 V617F	myeloproliferative neoplasm	predicted - sensitive	C220	Preclinical - Cell line xenograft	Actionable	In a preclinical study, C220 treatment inhibited cell proliferation of myeloproliferative neoplasm cell lines, including a Jakafi (ruxolitinib)-persistent cell line, expressing JAK2 V617F in culture, and inhibited tumor growth, with a 71% tumor reduction, in a cell line xenograft model (PMID: 32669286).	32669286
JAK2 V617F	myelofibrosis	predicted - sensitive	C220	Preclinical - Patient cell culture	Actionable	In a preclinical study, patient-derived primary myelofibrosis cells harboring JAK2 V617F and positive for CD34 were sensitive to C220 treatment in culture (PMID: 32669286).	32669286
JAK2 V617F	hematologic cancer	predicted - sensitive	C220	Preclinical - Cell culture	Actionable	In a preclinical study, C220 treatment inhibited proliferation of transformed cells expressing JAK2 V617F in culture (PMID: 32669286).	32669286
JAK2 V617F	polycythemia vera	predicted - sensitive	C220	Preclinical	Actionable	In a preclinical study, C220 treatment in a transgenic mouse model of polycythemia vera expressing JAK2 V617F resulted in decreased white blood cell counts, reduced spleen size with decreased extramedullary hematopoeisis, and decreased myeloproliferation, and altered the proportion of erythroid progenitors and erythroblasts (PMID: 32669286).	32669286

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