Therapy Detail
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| Therapy Name | Raludotatug deruxtecan |
| Synonyms | |
| Therapy Description |
Raludotatug deruxtecan (DS-6000a) is an antibody-drug conjugate (ADC) comprising a monoclonal antibody targeting CDH6 linked to the cytotoxic DNA topoisomerase inhibitor DXd, which binds to CDH6 expressed on tumor cells and potentially induces tumor cell apoptosis and inhibits tumor growth (PMID: 38205802). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Raludotatug deruxtecan | DS 6000a|DS-6000|DS6000a|DS-6000a|R-DXd | Raludotatug deruxtecan (DS-6000a) is an antibody-drug conjugate (ADC) comprising a monoclonal antibody targeting CDH6 linked to the cytotoxic DNA topoisomerase inhibitor DXd, which binds to CDH6 expressed on tumor cells and potentially induces tumor cell apoptosis and inhibits tumor growth (PMID: 38205802). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06161025 | Phase II | Paclitaxel Pegylated liposomal doxorubicin Raludotatug deruxtecan Topotecan Gemcitabine | A Study of Raludotatug Deruxtecan (R-DXd) in Subjects With Platinum-resistant, High-grade Ovarian, Primary Peritoneal, or Fallopian Tube Cancer | Active, not recruiting | USA | POL | ITA | GBR | FRA | ESP | DEU | CZE | CAN | AUS | 5 |
| NCT06660654 | Phase II | Raludotatug deruxtecan | A Study of Raludotatug Deruxtecan in Participants With Advanced/Metastatic Solid Tumors (REJOICE-PanTumor01) | Not yet recruiting | USA | 0 |
| NCT04707248 | Phase I | Raludotatug deruxtecan | A Study of DS-6000a in Subjects With Advanced Renal Cell Carcinoma and Ovarian Tumors | Recruiting | USA | 1 |
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