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Therapy Name ABBV-CLS-484
Synonyms
Therapy Description

ABBV-CLS-484 is a PTPN2/PTPN1 inhibitor, which activates JAK/STAT signaling, leading to remodeling of the tumor microenvironment, and potentially activation of an antitumor immune response and tumor growth inhibition (PMID: 37794185).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
ABBV-CLS-484 ABBV CLS 484|ABBV CLS484|AC484 ABBV-CLS-484 is a PTPN2/PTPN1 inhibitor, which activates JAK/STAT signaling, leading to remodeling of the tumor microenvironment, and potentially activation of an antitumor immune response and tumor growth inhibition (PMID: 37794185).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04777994 Phase I ABBV-CLS-484 + unspecified PD-1 antibody ABBV-CLS-484 A Phase 1 Study With ABBV-CLS-484 in Subjects With Locally Advanced or Metastatic Tumors Recruiting USA | ISR | FRA | ESP 2


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