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Therapy Detail
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| Therapy Name | BGB-15025 + Tislelizumab |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| BGB-15025 | BGB15025|BGB 15025 | MAP4K1 Inhibitor 8 | BGB-15025 is a small molecule inhibitor of MAP4K1 (HPK1), which may prevent immunosuppression in the tumor microenvironment and activate anti-tumor immune response (J Clin Oncol 42, 2024 (suppl 16; abstr 2585), NCI Drug Dictionary). | |
| Tislelizumab | Tevimbra | BGB-A317|tislelizumab-jsgr | Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 124 | Tevimbra (tislelizumab) is a human monoclonal antibody that targets PD-1 (PDCD1), thereby blocking the binding of PD-L1 (CD274) and potentially resulting in activation of a T-cell immune response against tumor cells (PMID: 32769013, PMID: 32561638, PMID: 32540858). Tevimbra (tislelizumab) is FDA-approved for use in patients with unresectable or metastatic esophageal squamous cell carcinoma (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04649385 | Phase I | BGB-15025 BGB-15025 + Tislelizumab | BGB-15025 Alone and in Combination With Anti-PD-1 Monoclonal Antibody Tislelizumab in Participants With Advanced Solid Tumors | Active, not recruiting | USA | NZL | AUS | 2 |
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