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Therapy Name PU-H71
Synonyms
Therapy Description

PU-H71 selectively inhibits Heat shock protein 90 (Hsp90), resulting in increased proteosomal degradation of oncogenic client proteins and potentially leading to decreased tumor growth (PMID: 28808818, PMID: 32156599).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
PU-H71 NSC 750424|PUH71|PU H71 HSP90 Inhibitor 35 PU-H71 selectively inhibits Heat shock protein 90 (Hsp90), resulting in increased proteosomal degradation of oncogenic client proteins and potentially leading to decreased tumor growth (PMID: 28808818, PMID: 32156599).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT01393509 Phase I PU-H71 The First-in-human Phase I Trial of PU-H71 in Patients With Advanced Malignancies Completed USA 0
NCT03935555 Phase I PU-H71 Assess the Safety, Tolerability Oral PU-H71 in Subjects Taking Ruxolitinib Terminated USA 0
NCT01581541 Phase I PU-H71 PU-H71 in Patients With Solid Tumors and Low-Grade Non-Hodgkin s Lymphoma That Have Not Responded to Standard Treatment Terminated USA 0


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