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Drug Name | PU-H71 |
Trade Name | |
Synonyms | NSC 750424|PUH71|PU H71 |
Drug Descriptions |
PU-H71 selectively inhibits Heat shock protein 90 (Hsp90), resulting in increased proteosomal degradation of oncogenic client proteins and potentially leading to decreased tumor growth (PMID: 28808818, PMID: 32156599). |
DrugClasses | HSP90 Inhibitor 35 |
CAS Registry Number | 873436-91-0 |
NCIT ID | C101227 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Buparlisib + PU-H71 | Buparlisib PU-H71 | 0 | 0 |
Dactolisib + PU-H71 | Dactolisib PU-H71 | 0 | 0 |
Nab-paclitaxel + PU-H71 | Nab-paclitaxel PU-H71 | 0 | 1 |
PU-H71 | PU-H71 | 0 | 3 |
PU-H71 + Ruxolitinib | PU-H71 Ruxolitinib | 0 | 1 |