Therapy Detail
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| Therapy Name | Idecabtagene Vicleucel + LY3039478 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Idecabtagene Vicleucel | Abecma | Ide-cel|bb2121|BMS-986395 | TNFRSF17 Immune Cell Therapy 27 | Abecma (idecabtagene vicleucel) is a chimeric antigen receptor T cell specific to B cell maturation antigen (BCMA), which could potentially result in decreased volume of BCMA expressing tumor cells (PMID: 32707894, PMID: 33626253). Abecma (idecabtagene vicleucel) is FDA approved for use in adult patients with relapsed or refractory multiple myeloma after four or more prior lines of therapy (FDA.gov). |
| LY3039478 | Crenigacestat|LY-3039478|JSMD194 | NOTCH Inhibitor (Pan) 5 | Crenigacestat (LY3039478) is a pan-NOTCH inhibitor, which may limit growth and survival of cancer cells (Cancer Res April 15, 2013 73; 1131, PMID: 32042099). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04855136 | Phase Ib/II | Iberdomide + Idecabtagene Vicleucel Idecabtagene Vicleucel + LY3039478 Bortezomib + Dexamethasone + Idecabtagene Vicleucel + Pomalidomide | Safety and Efficacy of bb2121 (Ide-cel) Combinations in Multiple Myeloma (KarMMa-7) | Terminated | USA | ESP | 0 |
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