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Therapy Detail
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| Therapy Name | KN046 |
| Synonyms | |
| Therapy Description |
KN046 is a bispecific monoclonal antibody that targets PD-L1 (CD274) expressed on tumor cells and CTLA-4 on T lymphocytes, potentially leading to enhanced antitumor immune response (PMID: 37263673). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| KN046 | KN 046|KN-046|Erfonrilimab | CTLA4 Antibody 33 Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 124 | KN046 is a bispecific monoclonal antibody that targets PD-L1 (CD274) expressed on tumor cells and CTLA-4 on T lymphocytes, potentially leading to enhanced antitumor immune response (PMID: 37263673). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04925947 | Phase II | KN046 | Phase II Study of KN046 in Patients With Thymic Carcinoma Who Failed Immune Checkpoint Inhibitors | Terminated | USA | 0 |
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