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Therapy Name OH2
Synonyms
Therapy Description

OH2 is an oncolytic herpes simplex virus-2 (HSV-2) engineered to include deletions in the viral genes ICP34.5 and ICP47, and to express human granulocyte macrophage colony stimulating factor (GM-CSF), which may lead to the activation of anti-tumor immune response and tumor cell killing (PMID: 32055679, PMID: 29872496).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
OH2 OH-2|OH 2|oHSV-2-expressing GM-CSF OH2 OH2 is an oncolytic herpes simplex virus-2 (HSV-2) engineered to include deletions in the viral genes ICP34.5 and ICP47, and to express human granulocyte macrophage colony stimulating factor (GM-CSF), which may lead to the activation of anti-tumor immune response and tumor cell killing (PMID: 32055679, PMID: 29872496).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CD274 positive esophageal cancer predicted - sensitive OH2 Case Reports/Case Series Actionable In a Phase I/II trial, OH2 treatment in a CD274 (PD-L1)-positive (TPS=3) metastatic esophageal cancer patient led to an immune partial response 5.44 months after treatment initiation, followed by discontinuation of treatment, and an ongoing response lasting over 14.03 months (PMID: 33837053). 33837053
CD274 positive rectum cancer predicted - sensitive OH2 Case Reports/Case Series Actionable In a Phase I/II trial, a patient with CD274 (PD-L1)-positive (TPS=3) metastatic rectal cancer treated with OH2 in a liver metastasis achieved a partial response with reduced size of the injected and non-injected liver lesions 6.89 months after treatment initiation and discontinued treatment but maintained an ongoing response lasting over 11.25 months (PMID: 33837053). 33837053

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries


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