Therapy Detail
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| Therapy Name | CC-96673 |
| Synonyms | |
| Therapy Description |
CC-96673 is a bispecific antibody that targets CD20 with high affinity and CD47 with low affinity and inhibits the interaction of CD47 with SIRPa, which potentially induces antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity against CD20-expressing tumor cells, increases phagocytosis of tumor cells, and inhibits tumor growth (PMID: 38349008). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| CC-96673 | CC 96673|CC96673|BMS-986358|BMS 986358|BMS986358 | CD20 Antibody 26 CD47 Antibody 31 | CC-96673 is a bispecific antibody that targets CD20 with high affinity and CD47 with low affinity and inhibits the interaction of CD47 with SIRPa, which potentially induces antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity against CD20-expressing tumor cells, increases phagocytosis of tumor cells, and inhibits tumor growth (PMID: 38349008). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04860466 | Phase I | CC-96673 | A Dose Finding Study of CC-96673 in Participants With Relapsed or Refractory Non-Hodgkin's Lymphoma | Terminated | USA | FRA | ESP | CAN | 0 |
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