Therapy Detail
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| Therapy Name | Camrelizumab + Rivoceranib + SHR9146 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Camrelizumab | SHR-1210|INCSHR-1210 | Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 121 | Camrelizumab (SHR-1210) is an antibody that targets PD-1 (PDCD1) and inhibits binding of PD-L1 (CD274) and PD-L2 (PDCD1LG2), potentially resulting in activation of anti-tumor immune response and decreased tumor growth (PMID: 29358502, PMID: 32623573, PMID: 32581041). | |
| Rivoceranib | YN968D1|Apatinib | KIT Inhibitor 57 RET Inhibitor 53 SRC Inhibitor 31 VEGFR2 Inhibitor 37 | Rivoceranib (apatinib) is an inhibitor of receptor tyrosine kinases, including KDR (VEGFR2), RET, c-KIT, Src, and PDGFRa, which may result in reduced cell proliferation and inhibition of tumor growth (PMID: 21443688, PMID: 32669874). | |
| SHR9146 | SHR 9146|SHR-9146|HTI-1090|HTI 1090|HTI1090 | IDO1 Inhibitor 12 | SHR9146 inhibits IDO1, which may block immune suppression in tumor microenvironment and enhance antitumor immune response (J Clin Oncol 39, no. 15_suppl (May 20, 2021) 3101-3101). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|
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