Therapy Detail
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| Therapy Name | ABBV-514 |
| Synonyms | |
| Therapy Description |
ABBV-514 is an afucosylated antibody targeting CCR8, which potentially induces antibody-dependent cellular cytotoxicity (ADCC) and depletion of CCR8-positive regulatory T-cells (Cancer Res (2025) 85 (8_Supplement_1): 6025). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| ABBV-514 | ABBV514|ABBV 514 | CCR8 Antibody 13 | ABBV-514 is an afucosylated antibody targeting CCR8, which potentially induces antibody-dependent cellular cytotoxicity (ADCC) and depletion of CCR8-positive regulatory T-cells (Cancer Res (2025) 85 (8_Supplement_1): 6025). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05005403 | Phase I | ABBV-514 + Budigalimab ABBV-514 ABBV-514 + Bevacizumab | Study to Assess Adverse Events and Pharmacokinetics in Adult Participants With Non-Small Cell Lung Cancer (NSCLC), Head and Neck Squamous Cell Carcinoma (HNSCC) and Other Solid Tumors, Receiving Intravenous (IV) Infusion of Azirkitug (ABBV-514) Alone or in Combination With Budigalimab or Bevacizumab | Recruiting | USA | ISR | 3 |
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