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Therapy Name REGN4336
Synonyms
Therapy Description

REGN4336 is a a bispecific antibody that targets prostate-specific membrane antigen (PSMA) expressed on tumor cells and the CD3 antigen expressed on T-lymphocytes, potentially leading to activation and recruitment of cytotoxic T-lymphocytes (CTL) to tumor cells expressing PSMA and CTL-mediated tumor cell killing (NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
REGN4336 REGN-4336|REGN 4336 CD3 Antibody 99 PSMA Antibody 20 REGN4336 is a a bispecific antibody that targets prostate-specific membrane antigen (PSMA) expressed on tumor cells and the CD3 antigen expressed on T-lymphocytes, potentially leading to activation and recruitment of cytotoxic T-lymphocytes (CTL) to tumor cells expressing PSMA and CTL-mediated tumor cell killing (NCI Drug Dictionary).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05125016 Phase Ib/II REGN4336 Cemiplimab + REGN4336 REGN4336 (a PSMAXCD3 Bispecific Antibody) Administered Alone or in Combination With Cemiplimab in Adult Male Patients With Metastatic Castration-Resistant Prostate Cancer Recruiting USA 0


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