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Therapy Detail
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| Therapy Name | Modotuximab + S095029 + Sym021 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Modotuximab | 1024 DS|1024-DS|Zatuximab | EGFR Antibody 64 | Modotuximab (1024 DS) is a recombinant human-mouse chimeric monoclonal antibody that targets a specific EGFR epitope (PMID: 29564747). | |
| S095029 | S-095029|S 095029|Sym 025|Sym-025|Sym025 | NKG2A Antibody 3 | S095029 is a monoclonal antibody that targets natural killer (NK) and T-lymphocyte cell checkpoint inhibitor killer cell lectin-like receptor subfamily C member 1 (NKG2A), which may result in an antitumor immune response mediated by NK cells and cytotoxic T-lymphocytes (NCI Drug Dictionary). | |
| Sym021 | Sym-021|Sym 021 | Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 124 | Sym021 is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 3822, PMID: 31046547, PMID: 31754392). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05162755 | Phase I | S095029 S095029 + Sym021 Futuximab + S095029 + Sym021 Modotuximab + S095029 + Sym021 | S095029 as Monotherapy and in Combination With Sym021 in Patients With Advanced Solid Tumor Malignancies Followed by an Expansion Part With Triple Combinations in Patients With Metastatic Gastric or Colorectal Cancers | Active, not recruiting | USA | CAN | 0 |
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