Therapy Detail
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| Therapy Name | 177Lu-girentuximab |
| Synonyms | |
| Therapy Description |
177Lu-girentuximab is a radioconjugate comprising girentuximab (TLX250), a monoclonal antibody that targets CA9 (CAIX), conjugated to the radionuclide lutetium 177, which delivers radiation to tumor cells and potentially results in inhibition of tumor growth (PMID: 14960657, PMID: 22980441, PMID: 40227816). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| 177Lu-girentuximab | 177Lu-DOTA-cG250|Lu-177 girentuximab|177Lu-TLX250|[177Lu]-TLX250 | 177Lu-girentuximab is a radioconjugate comprising girentuximab (TLX250), a monoclonal antibody that targets CA9 (CAIX), conjugated to the radionuclide lutetium 177, which delivers radiation to tumor cells and potentially results in inhibition of tumor growth (PMID: 14960657, PMID: 22980441, PMID: 40227816). |
Filtering
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07197580 | Phase III | 177Lu-girentuximab | Study of 177Lu-TLX250 in Advanced Relapsed or Recurrent ccRCC (LUTEON) | Not yet recruiting | AUS | 0 |
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