Therapy Detail
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| Therapy Name | P-MUC1C-ALLO1 CAR-T cells + Rimiducid |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| P-MUC1C-ALLO1 CAR-T cells | P-MUC1C-ALLO1 CAR-T are allogeneic T-cells engineered to target MUC1C, with potential antitumor activity (Journal for ImmunoTherapy of Cancer 2020;8, Issue Suppl 3). | |||
| Rimiducid | AP1903|AP-1903|AP 1903 | Rimiducid (AP1903) is a small molecule that selectively binds to mutant FKBP12 and induces dimerization and downstream signaling, which can be used to activate a safety switch in transplanted cells to potentially induce apoptosis and prevent graft-versus-host disease (PMID: 9724721, PMID: 22047558, PMID: 28697888). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05239143 | Phase I | P-MUC1C-ALLO1 CAR-T cells + Rimiducid | P-MUC1C-ALLO1 Allogeneic CAR-T Cells in the Treatment of Subjects With Advanced or Metastatic Solid Tumors | Active, not recruiting | USA | 0 |
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