Therapy Detail
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| Therapy Name | IMU-131 + Paclitaxel |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| IMU-131 | HER-Vaxx|IMU131|IMU 131 | HER2 (ERBB2) Vaccine 14 | IMU-131 is a B-cell vaccine comprised of 3 ERBB2 (HER2) extracellular epitopes conjugated to CRM197 (PMID: 33879458), potentially inducing polyclonal antibody response and anti-proliferative activity (PMID: 28183282). | |
| Paclitaxel | Taxol | 7-Epipaclitaxel | Antimicrotubule Agent 14 BCL2 Family Inhibitor 6 | Taxol (paclitaxel) binds to tubulin to inhibit microtubule disassembly, which results in decreased cell division, and also binds to the anti-apoptotic factor Bcl-2, promoting apoptosis (NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|
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