Therapy Detail
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| Therapy Name | AZD8205 |
| Synonyms | |
| Therapy Description |
AZD8205 is a an antibody-drug conjugate (ADC) comprising a B7-H4 targeted antibody linked to a topoisomerase inhibitor, which potentially leads to apoptosis of B7-H4-expressing tumor cells and inhibition of tumor growth (Cancer Res 2022;82(12_Suppl):Abstract nr 1765). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| AZD8205 | AZD 8205|AZD-8205|Puxitatug Samrotecan | AZD8205 is a an antibody-drug conjugate (ADC) comprising a B7-H4 targeted antibody linked to a topoisomerase inhibitor, which potentially leads to apoptosis of B7-H4-expressing tumor cells and inhibition of tumor growth (Cancer Res 2022;82(12_Suppl):Abstract nr 1765). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07044336 | Phase III | AZD8205 Paclitaxel Doxorubicin | Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4-selected Endometrial Cancer (Bluestar-Endometrial01) | Recruiting | USA | SVN | ITA | ISR | HUN | GRC | GBR | FRA | FIN | ESP | DEU | CZE | CAN | BRA | BEL | AUT | AUS | ARG | 5 |
| NCT05123482 | Phase Ib/II | AZD2936 + AZD8205 AZD2936 + AZD8205 + Saruparib AZD8205 AZD8205 + Saruparib AZD8205 + AZD9574 AZD2936 + AZD8205 + AZD9574 | A Phase I/IIa Study of AZD8205 Given Alone or in Combination With Anticancer Drugs, in Participants With Advanced or Metastatic Solid Malignancies | Recruiting | USA | POL | NLD | ITA | HUN | GBR | ESP | CAN | BEL | AUS | 5 |
| NCT07162480 | Phase II | AZD8205 | Phase II Trial of Puxitatug Samrotecan (AZD8205) in Advanced, Recurrent or Metastatic (R/M) Aggressive Adenoid Cystic Carcinoma Subtype I (ACC-I) | Not yet recruiting | USA | 0 |
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