Therapy Detail
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| Therapy Name | BMS986158 + CC-92480 + Dexamethasone |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| BMS986158 | BMS-986158|BMS 986158 | BET Inhibitor (Pan) 33 | BMS986158 is BET inhibitor, which interferes with chromatin remodeling to prevent gene expression and tumor growth (PMID: 32286255). | |
| CC-92480 | CELMoD CC92480|CC 92480|Mezigdomide|BMS-986348|BMS986348|BMS 986348 | CC-92480 binds to and modulates activity of the ubiquitin E3 ligase complex member Cereblon (CRBN), which may induce ubiquitination and degradation of transcription factors in T-lymphocytes, resulting in immune system activation (Blood (2019) 134 (Supplement_1): 1812, PMID: 32130004). | ||
| Dexamethasone | Adexone | Desametasone |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05372354 | Phase Ib/II | CC-92480 + Dexamethasone + Tazemetostat CC-92480 + Dexamethasone + Trametinib BMS986158 + CC-92480 + Dexamethasone CC-92480 + Dexamethasone | A Study to Evaluate Safety, Drug Levels and Effectiveness of CC-92480 (BMS-986348) in Combination With Other Treatments in Participants With Relapsed or Refractory Multiple Myeloma | Recruiting | USA | NOR | GBR | ESP | CAN | 0 |
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