Therapy Detail
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| Therapy Name | LOXO-783 + LY3484356 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| LOXO-783 | LOXO 783|LOXO783|LOX-22783|LOX 22783|LOX22783 | PIK3CA inhibitor 24 | LOXO-783 (LOX-22783) selectively inhibits PIK3CA H1047R leading to decreased downstream signaling and potentially resulting in tumor growth inhibition (Mol Cancer Ther 2021;20(12 Suppl):Abstract nr P142). | |
| LY3484356 | LY 3484356|LY-3484356|SERD LY3484356|imlunestrant | Hormone - Anti-estrogens 29 | LY3484356 is a selective estrogen receptor degrader that binds to and causes the degradation of the estrogen receptor (ER), potentially leading to decreased ER signaling and antitumor activity (J Clin Oncol 39, no. 15_suppl (May 20, 2021) 1050-1050). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05307705 | Phase I | Abemaciclib + Anastrozole + LOXO-783 Abemaciclib + Exemestane + LOXO-783 Abemaciclib + Letrozole + LOXO-783 LOXO-783 + Paclitaxel Fulvestrant + LOXO-783 LOXO-783 + LY3484356 Abemaciclib + Fulvestrant + LOXO-783 Abemaciclib + LOXO-783 + LY3484356 Letrozole + LOXO-783 LOXO-783 Anastrozole + LOXO-783 Exemestane + LOXO-783 | A Study of LOXO-783 in Patients With Breast Cancer/Other Solid Tumors (PIKASSO-01) | Active, not recruiting | USA | ITA | GBR | FRA | ESP | DEU | CAN | BEL | AUS | 4 |
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