Imlunestrant
Drug Detail

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Drug Name Imlunestrant
Trade Name Inluriyo
Synonyms LY 3484356|LY-3484356|SERD LY3484356|LY3484356
Drug Descriptions

Inluriyo (imlunestrant) is a selective estrogen receptor degrader that binds to and causes the degradation of the estrogen receptor (ER), potentially leading to decreased ER signaling and antitumor activity (J Clin Oncol 39, no. 15_suppl (May 20, 2021) 1050-1050). Inluriyo (imlunestrant) is FDA-approved for use in patients with estrogen receptor-positive, ERBB2 (HER2)-negative, advanced or metastatic breast cancer harboring ESR1 (ER alpha) mutations who have progressed after at least one line of endocrine therapy (FDA.gov).

DrugClasses Hormone - Anti-estrogens 31
CAS Registry Number NA
NCIT ID C174042

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + Anastrozole + Imlunestrant Abemaciclib Anastrozole Imlunestrant 0 1
Abemaciclib + Exemestane + Imlunestrant Abemaciclib Exemestane Imlunestrant 0 1
Abemaciclib + Imlunestrant Abemaciclib Imlunestrant 0 3
Abemaciclib + Imlunestrant + Letrozole Abemaciclib Imlunestrant Letrozole 0 1
Abemaciclib + Imlunestrant + LOXO-783 Abemaciclib Imlunestrant LOXO-783 0 1
Abemaciclib + Imlunestrant + Trastuzumab Abemaciclib Imlunestrant Trastuzumab 0 1
Alpelisib + Imlunestrant Alpelisib Imlunestrant 0 1
Capecitabine + Imlunestrant Capecitabine Imlunestrant 0 0
Everolimus + Imlunestrant Everolimus Imlunestrant 0 1
Imlunestrant Imlunestrant 0 4
Imlunestrant + LOXO-783 Imlunestrant LOXO-783 0 1
Imlunestrant + LY4257496 Imlunestrant LY4257496 0 0


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