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Therapy Name NTX-1088
Synonyms
Therapy Description

NTX-1088 is a monoclonal antibody that targets the poliovirus receptor (PVR, CD155), thereby preventing its interaction with CD96 and TIGIT as well as DNAM1 (CD226), potentially leading to enhanced antitumor immune response and inhibition of tumor growth (Cancer Immunol Res 2022;10(1 Suppl):Abstract nr P075).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
NTX-1088 NTX 1088|NTX1088 NTX-1088 is a monoclonal antibody that targets the poliovirus receptor (PVR, CD155), thereby preventing its interaction with CD96 and TIGIT as well as DNAM1 (CD226), potentially leading to enhanced antitumor immune response and inhibition of tumor growth (Cancer Immunol Res 2022;10(1 Suppl):Abstract nr P075).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05378425 Phase I NTX-1088 NTX-1088 + Pembrolizumab A Study of NTX-1088, a Monoclonal Antibody Targeting the Poliovirus Receptor (PVR, CD155), as Monotherapy and Combined With Pembrolizumab Recruiting USA | ISR 0


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