Therapy Detail
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| Therapy Name | Azacitidine + Bleximenib |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Azacitidine | Vidaza | azacytidine|CC-486|5-azacytidine|5-AC|U-18496|Onureg | DNMT inhibitor (Pan) 5 | Vidaza (azacitidine) is a cytidine analog that incorporates into DNA and RNA and binds to DNA methyltransferases (DNMTs), resulting in DNMT degradation and decreased DNA methylation, and leading to increased tumor cell death (PMID: 28159832, PMID: 28067760). Vidaza (azacitidine) is FDA-approved for use in patients with some subtypes of myelodysplastic syndrome and Onureg (azacitidine) is FDA approved for use in continued treatment of acute myeloid leukemia(FDA.gov). |
| Bleximenib | JNJ 75276617|JNJ75276617|JNJ-75276617 | MEN1-KMT2A Inhibitor 8 | Bleximenib inhibits the interaction between menin and MLL, leading to decreased expression of target genes, which potentially inhibits proliferation of tumor cells harboring KMT2A rearrangements or NPM1 mutations (PMID: 38905635). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05453903 | Phase I | Bleximenib + Venetoclax Azacitidine + Bleximenib + Venetoclax Azacitidine + Bleximenib | A Study of Bleximenib in Combination With Acute Myeloid Leukemia (AML) Directed Therapies | Recruiting | USA | ITA | GBR | FRA | ESP | DEU | CAN | AUS | 0 |
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