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Drug Name Bleximenib
Trade Name
Synonyms JNJ 75276617|JNJ75276617|JNJ-75276617
Drug Descriptions

Bleximenib inhibits the interaction between menin and MLL, leading to decreased expression of target genes, which potentially inhibits proliferation of tumor cells harboring KMT2A rearrangements or NPM1 mutations (PMID: 38905635).

DrugClasses MEN1-KMT2A Inhibitor 8
CAS Registry Number 2654081-35-1
NCIT ID C179561

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Azacitidine + Bleximenib Azacitidine Bleximenib 0 1
Azacitidine + Bleximenib + Venetoclax Azacitidine Bleximenib Venetoclax 0 1
Bleximenib Bleximenib 0 1
Bleximenib + Cytarabine + Dexamethasone + Fludarabine + Pegaspargase + Vincristine Sulfate Bleximenib Cytarabine Dexamethasone Fludarabine Pegaspargase Vincristine Sulfate 0 1
Bleximenib + Gilteritinib Bleximenib Gilteritinib 0 0
Bleximenib + Venetoclax Bleximenib Venetoclax 0 1


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