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Therapy Name M9140
Synonyms
Therapy Description

M9140 is an antibody-drug conjugate (ADC) comprising a monoclonal antibody targeting CEACAM5 linked to the topoisomerase I inhibitor exatecan, which potentially induces antitumor activity (Ann Oncol (2024) 35 (Suppl_2): S466; J Clin Oncol (2024) 42:16_suppl, 3000).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
M9140 M-9140|M 9140 CEACAM5 Antibody 8 M9140 is an antibody-drug conjugate (ADC) comprising a monoclonal antibody targeting CEACAM5 linked to the topoisomerase I inhibitor exatecan, which potentially induces antitumor activity (Ann Oncol (2024) 35 (Suppl_2): S466; J Clin Oncol (2024) 42:16_suppl, 3000).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05464030 Phase I M9140 Anti-CEACAM5 ADC M9140 in Advanced Solid Tumors Recruiting USA | ESP | CAN 2


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