Therapy Detail
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| Therapy Name | Bevacizumab + M9140 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Bevacizumab | Avastin | VEGF Antibody 17 VEGFR Inhibitor (Pan) 36 | Avastin (bevacizumab) is a monoclonal antibody that binds VEGF and inhibits binding to VEGFR, potentially resulting in decreased tumor growth (PMID: 15136787). Avastin (bevacizumab) is FDA approved for use in colorectal cancer, non-small cell lung cancer, glioblastoma, renal cell carcinoma, cervical carcinoma, and ovarian cancer, and in combination with carboplatin and paclitaxel in epithelial ovarian, fallopian tube, or primary peritoneal cancer (FDA.gov). | |
| M9140 | M-9140|M 9140|Precemtabart Tocentecan | CEACAM5 Antibody 13 | M9140 is an antibody-drug conjugate (ADC) comprising a monoclonal antibody targeting CEACAM5 linked to the topoisomerase I inhibitor exatecan, which potentially induces antitumor activity (Ann Oncol (2024) 35 (Suppl_2): S466; J Clin Oncol (2024) 42:16_suppl, 3000). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07549412 | Phase III | M9140 Bevacizumab + M9140 Bevacizumab + Trifluridine-tipiracil hydrochloride | A Study of Precemtabart Tocentecan With or Without Bevacizumab Compared to Trifluridine/Tipiracil Plus Bevacizumab in Participants With Previously Treated Metastatic Colorectal Cancer (PROCEADE-CRC-03) | Not yet recruiting | USA | DEU | 0 |
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