Therapy Detail
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| Therapy Name | SAR443579 |
| Synonyms | |
| Therapy Description |
SAR443579 is a trispecific natural killer (NK) cell engager (NKCE) targeting tumor-expressed CD123 (IL3RA), and the NK-cell specific receptors NKp46 and CD16, potentially leading to NK cell-mediated killing of tumor cells expressing CD123 (IL3RA) (J Clin Oncol 41, 2023 (suppl 16; abstr 7005)). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| SAR443579 | SAR-443579|SAR 443579|IPH 6101|IPH-6101|IPH6101|bexatamig | CD123 (IL3RA) Antibody 14 | SAR443579 is a trispecific natural killer (NK) cell engager (NKCE) targeting tumor-expressed CD123 (IL3RA), and the NK-cell specific receptors NKp46 and CD16, potentially leading to NK cell-mediated killing of tumor cells expressing CD123 (IL3RA) (J Clin Oncol 41, 2023 (suppl 16; abstr 7005)). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05086315 | Phase Ib/II | SAR443579 | First-in-human Study of SAR443579 Infusion in Male and Female Participants of at Least 12 Years of Age With Relapsed or Refractory Acute Myeloid Leukemia (R/R AML), B-cell Acute Lymphoblastic Leukemia (B-ALL) or High Risk-myelodysplasia (HR-MDS) | Terminated | USA | NLD | FRA | AUS | 1 |
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