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Therapy Name SAR443579
Synonyms
Therapy Description

SAR443579 is a trispecific natural killer (NK) cell engager (NKCE) comprised of antibodies targeting tumor-expressed CD123, and the NK-cell specific receptors NKp46 and CD16, potentially leading to NK cell-mediated killing of tumor cells expressing CD123 (J Clin Oncol 41, 2023 (suppl 16; abstr 7005)).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
SAR443579 SAR-443579|SAR 443579|IPH 6101|IPH-6101|IPH6101 SAR443579 is a trispecific natural killer (NK) cell engager (NKCE) comprised of antibodies targeting tumor-expressed CD123, and the NK-cell specific receptors NKp46 and CD16, potentially leading to NK cell-mediated killing of tumor cells expressing CD123 (J Clin Oncol 41, 2023 (suppl 16; abstr 7005)).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05086315 Phase Ib/II SAR443579 First-in-human Study of SAR443579 Infusion in Male and Female Participants of at Least 12 Years of Age With Relapsed or Refractory Acute Myeloid Leukemia (R/R AML), B-cell Acute Lymphoblastic Leukemia (B-ALL) or High Risk-myelodysplasia (HR-MDS) Recruiting USA | NLD | FRA | AUS 1


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