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Therapy Name YH004
Synonyms
Therapy Description

YH004 is an agonistic monoclonal antibody that targets CD137 (4-1BB; TNFRSF9), resulting in increased CD137 signaling and potentially leading to inhibition of T-regulatory cells and induction of a cytotoxic T-lymphocyte (CTL)- and NK cell-mediated antitumor response, resulting in tumor cell killing (NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
YH004 YH 004|YH-004 TNFRSF9 Antibody 32 YH004 is an agonistic monoclonal antibody that targets CD137 (4-1BB; TNFRSF9), resulting in increased CD137 signaling and potentially leading to inhibition of T-regulatory cells and induction of a cytotoxic T-lymphocyte (CTL)- and NK cell-mediated antitumor response, resulting in tumor cell killing (NCI Drug Dictionary).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05040932 Phase I YH004 Study of YH004 (4-1BB Agonist Antibody) in Advanced or Metastatic Malignancy Completed AUS 0


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