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Therapy Name ABL503
Synonyms
Therapy Description

ABL503 is a bispecific antibody that targets both CD274 (PD-L1) and TNFRSF9 (4-1BB), leading to activation of TNFRSF9 (4-1BB) and decreased CD274 (PD-L1) signaling, potentially resulting in activation of an antitumor immune response and inhibition of tumor growth (PMID: 34230109).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
ABL503 ABL-503|ABL 503|TJ-L14B|ragistomig PD-L1/PD-1 antibody 133 TNFRSF9 Antibody 36 ABL503 is a bispecific antibody that targets both CD274 (PD-L1) and TNFRSF9 (4-1BB), leading to activation of TNFRSF9 (4-1BB) and decreased CD274 (PD-L1) signaling, potentially resulting in activation of an antitumor immune response and inhibition of tumor growth (PMID: 34230109).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04762641 Phase I ABL503 This is a Study to Evaluate the Safety and Tolerability of ABL503, and to Determine the Maximum Tolerated Dose (MTD) and Recommended Phase 2 Dose (RP2D) of ABL503 in Subjects With Any Progressive Locally Advanced or Metastatic Solid Tumors Recruiting USA 1


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