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Therapy Name BAFFR-CAR T cells
Synonyms
Therapy Description

BAFFR-CAR T cells are T-lymphocytes engineered to express a chimeric antigen receptor (CAR) that targets B-cell activating factor receptor (BAFF-R) and containing TNFRSF9 (4-1BB) and CD3zeta signaling domains, which potentially result in cytotoxic effects against tumor cells (PMID: 31554741).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
BAFFR-CAR T cells Autologous BAFFR-CAR-expressing T-cells BAFFR-CAR T cells are T-lymphocytes engineered to express a chimeric antigen receptor (CAR) that targets B-cell activating factor receptor (BAFF-R) and containing TNFRSF9 (4-1BB) and CD3zeta signaling domains, which potentially result in cytotoxic effects against tumor cells (PMID: 31554741).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05370430 Phase I BAFFR-CAR T cells BAFFR-targeting CAR T Cells for Patients With Relapsed or Refractory B-NHL Recruiting USA 0
NCT06191887 Phase I Bendamustine BAFFR-CAR T cells Cyclophosphamide + Fludarabine B-Cell Activating Factor Receptor (BAFFR)-Based Chimeric Antigen Receptor T-Cells With Fludarabine and Cyclophosphamide Lymphodepletion for the Treatment of Relapsed or Refractory B-cell Hematologic Malignancies Recruiting USA 0
NCT04690595 Phase I BAFFR-CAR T cells BAFFR Targeting CAR-T Cells for the Treatment of Relapsed or Refractory B-cell ALL Recruiting USA 0


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