Therapy Detail
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| Therapy Name | ODM-208 |
| Synonyms | |
| Therapy Description |
ODM-208 is a selective inhibitor of CYP11A1, which potentially inhibits steroid biosynthesis and tumor growth (PMID: 36129801). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| ODM-208 | ODM208|ODM 208|MK-5684|MK5684|MK 5684|Opevesostat | ODM-208 is a selective inhibitor of CYP11A1, which potentially inhibits steroid biosynthesis and tumor growth (PMID: 36129801). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03436485 | Phase Ib/II | ODM-208 | Safety and Pharmacokinetics of ODM-208 in Patients With Metastatic Castration-resistant Prostate Cancer (CYPIDES) | Active, not recruiting | USA | GBR | FRA | FIN | 0 |
| NCT06353386 | Phase Ib/II | ODM-208 ODM-208 + Olaparib Docetaxel + ODM-208 Cabazitaxel + ODM-208 | Substudy 01A: Safety and Efficacy of Opevesostat (MK-5684)-Based Treatment Combinations or Opevesostat Alone in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-5684-01A) | Recruiting | USA | TUR | POL | NZL | ITA | ISR | IRL | GBR | FRA | FIN | ESP | DNK | DEU | CAN | AUS | 5 |
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